Adaptive randomization procedures for the web-based randomization system RANDI2.
نویسندگان
چکیده
©2012 Dustri-Verlag Dr. K. Feistle ISSN 0946-1965 DOI 10.5414/CPP50085 e-pub: December 28, 2011
منابع مشابه
Possible combinations of electronic data capture and randomization systems. principles and the realization with RANDI2 and OpenClinica.
BACKGROUND Clinical trials (CT) are in a wider sense experiments to prove and establish clinical benefit of treatments. Nowadays electronic data capture systems (EDCS) are used more often bringing a better data management and higher data quality into clinical practice. Also electronic systems for the randomization are used to assign the patients to the treatments. OBJECTIVES If the mentioned ...
متن کاملPossible Combinations of Electronic Data Capture and Randomization Systems
Background: Clinical trials (CT) are in a wider sense experiments to prove and establish clinical benefit of treatments. Nowadays electronic data capture systems (EDCS) are used more often bringing a better data management and higher data quality into clinical practice. Also electronic systems for the randomization are used to assign the patients to the treatments. Objectives: If the mentioned ...
متن کاملAn Easily Accessible Web-Based Minimization Random Allocation System for Clinical Trials
BACKGROUND Minimization as an adaptive allocation technique has been recommended in the literature for use in randomized clinical trials. However, it remains uncommonly used due in part to a lack of easily accessible implementation tools. OBJECTIVE To provide clinical trialists with a robust, flexible, and readily accessible tool for implementing covariate-adaptive biased-coin randomization. ...
متن کاملRandomization in clinical trials: conclusions and recommendations.
The statistical properties of simple (complete) randomization, permuted-block (or simply blocked) randomization, and the urn adaptive biased-coin randomization are summarized. These procedures are contrasted to covariate adaptive procedures such as minimization and to response adaptive procedures such as the play-the-winner rule. General recommendations are offered regarding the use of complete...
متن کاملA Graphical Method for Comparing Response-Adaptive Randomization Procedures
Abstract Response-adaptive randomization procedures have a dual goal of estimating the treatment effect and randomizing patients with a higher probability of receiving the superior treatment. These are competing objectives, and no procedure in the literature is “perfect” with respect to both objectives. For clinical trials of two treatments, we discuss metrics for comparing response-adaptive ra...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- International journal of clinical pharmacology and therapeutics
دوره 50 1 شماره
صفحات -
تاریخ انتشار 2012